Types of Hyperlipidemia and how to manage it

What is Hyperlipidemia

• Also known as high cholesterol, is a medical condition where the body has too much cholesterol.

Types of cholesterol

• Low-density lipoprotein (LDL) is a bad cholesterol as it increases the risk of plague buildup, plague rupture and cardiovascular disease (CVD).
• High-density lipoprotein (HDL) is a good cholesterol that removes cholesterol from cells before they are deposited as plague in the arteries.
• Triglyceride (TG) is the most common type of cholesterol which stores excessive energy from one's diet. High level of TG, together with a high level of LDL, increases the risk of CVD.

Medications and treatment

• Statins slows production of LDL in the liver. It also increases the liver's ability to remove LDL.
• PCS K9 inhibitors are proteins that degrades LDL receptors and increases its absorption into the liver cells.
  • Represented by two brands: Praluent and Repatha.
  • Subcutaneously injected every two weeks. 
• Inclisiran reduces upstream PCS K9 production and increases LDL absorption.
  • Goes by the trade name of LEQVIO
  • Injected once every six months